Skip to main content

Polarna površina molekula Vidi još Reference Spoljašnje veze Мени за навигацију10.1021/jm000942ePolar Surface AreaInteractive Polar Surface Area calculatorFree, Programmable TPSA Calculator

ХеминформатикаМедицинска хемија


engl.kiseonikaazotamedicinskoj hemijiangstromakrvno-moždanu barijerucentralnog nervnog sistema










(function()var node=document.getElementById("mw-dismissablenotice-anonplace");if(node)node.outerHTML="u003Cdiv class="mw-dismissable-notice"u003Eu003Cdiv class="mw-dismissable-notice-close"u003E[u003Ca tabindex="0" role="button"u003Eсакријu003C/au003E]u003C/divu003Eu003Cdiv class="mw-dismissable-notice-body"u003Eu003Cdiv id="localNotice" lang="sr" dir="ltr"u003Eu003Cdiv class="noticebanner"u003Eu003Cdiv class="plainlinks" style="background-image: -moz-linear-gradient(top, #fefefe, #fefefe, #f0f0f0); background-image: -o-linear-gradient(top, #fefefe, #fefefe, #f0f0f0); background-image: -webkit-linear-gradient(top, #fefefe, #fefefe, #f0f0f0); background-image: linear-gradient(to bottom, #fefefe, #fefefe, #f0f0f0);; -moz-border-radius: 10px; -webkit-border-radius: 10px; border-radius:10px; margin-top:10px; position:relative; height:25px; border-style:solid; border-width:1px; color:#aaa; border-color:u0026#32;; border:; font-family: u0026#39;Helveticau0026#39;, u0026#39;Arialu0026#39;, sans-serif; line-height: 18px; background-color:; overflow:hidden;"u003Eu003Cdiv style="display:block; position: absolute; top:4px; width:100%; text-align:center;;"u003Eu003Cdiv style="font-weight:bold; color:#000085; font-size:14px; line-height:25px"u003Eu003Cdiv style="padding-left:50px;"u003Eu003C/divu003Eu003C/divu003Eu003Cdiv style="margin-top: 2px; font-weight:normal; color:#555; font-size:15px; line-height:15px;"u003Eu003Cdiv style="padding-left:50px;"u003EУчествуј у u003Cbu003Eu003Ca href="https://meta.wikimedia.org/wiki/%D0%92%D0%B5%D0%BB%D0%B8%D0%BA%D0%BE_%D0%BF%D1%80%D0%BE%D0%BB%D0%B5%D1%9B%D0%BD%D0%BE_%D1%81%D1%80%D0%B5%D1%92%D0%B8%D0%B2%D0%B0%D1%9A%D0%B5_%D0%9E%D1%81%D1%82%D0%B0%D0%B2%D0%B5" class="extiw" title="meta:Велико пролећно сређивање Оставе"u003EВеликом пролећном сређивању Оставеu003C/au003Eu003C/bu003E од 15. марта до 15. априла!u003C/divu003Eu003C/divu003Eu003C/divu003Eu003C/divu003Eu003C/divu003Enu003Cdiv class="noticebanner"u003Eu003Cdiv class="plainlinks" style="background-image: -moz-linear-gradient(top, #fefefe, #fefefe, #f0f0f0); background-image: -o-linear-gradient(top, #fefefe, #fefefe, #f0f0f0); background-image: -webkit-linear-gradient(top, #fefefe, #fefefe, #f0f0f0); background-image: linear-gradient(to bottom, #fefefe, #fefefe, #f0f0f0);; -moz-border-radius: 10px; -webkit-border-radius: 10px; border-radius:10px; margin-top:10px; position:relative; height:25px; border-style:solid; border-width:1px; color:#aaa; border-color:u0026#32;; border:; font-family: u0026#39;Helveticau0026#39;, u0026#39;Arialu0026#39;, sans-serif; line-height: 18px; background-color:; overflow:hidden;"u003Eu003Cdiv style="display:block; position: absolute; top:4px; width:100%; text-align:center;;"u003Eu003Cdiv style="font-weight:bold; color:#000085; font-size:14px; line-height:25px"u003Eu003Cdiv style="padding-left:50px;"u003Eu003C/divu003Eu003C/divu003Eu003Cdiv style="margin-top: 2px; font-weight:normal; color:#555; font-size:15px; line-height:15px;"u003Eu003Cdiv style="padding-left:50px;"u003EТакмичи се у писању u003Cbu003Eu003Ca href="/wiki/%D0%92%D0%B8%D0%BA%D0%B8%D0%BF%D0%B5%D0%B4%D0%B8%D1%98%D0%B0:%D0%A2%D0%B0%D0%BA%D0%BC%D0%B8%D1%87%D0%B5%D1%9A%D0%B5_%D1%83_%D0%BF%D0%B8%D1%81%D0%B0%D1%9A%D1%83_%D1%87%D0%BB%D0%B0%D0%BD%D0%B0%D0%BA%D0%B0/%D0%A6%D0%95%D0%95_%D0%BF%D1%80%D0%BE%D0%BB%D0%B5%D1%9B%D0%B5_2019" title="Википедија:Такмичење у писању чланака/ЦЕЕ пролеће 2019"u003Eчланака о средњој и источној Европиu003C/au003Eu003C/bu003E од 21. марта до 31. маја!u003C/divu003Eu003C/divu003Eu003C/divu003Eu003C/divu003Eu003C/divu003Enu003Cdiv class="noticebanner"u003Eu003Cdiv class="plainlinks" style="background-image: -moz-linear-gradient(top, #fefefe, #fefefe, #f0f0f0); background-image: -o-linear-gradient(top, #fefefe, #fefefe, #f0f0f0); background-image: -webkit-linear-gradient(top, #fefefe, #fefefe, #f0f0f0); background-image: linear-gradient(to bottom, #fefefe, #fefefe, #f0f0f0);; -moz-border-radius: 10px; -webkit-border-radius: 10px; border-radius:10px; margin-top:10px; position:relative; height:25px; border-style:solid; border-width:1px; color:#aaa; border-color:u0026#32;; border:; font-family: u0026#39;Helveticau0026#39;, u0026#39;Arialu0026#39;, sans-serif; line-height: 18px; background-color:; overflow:hidden;"u003Eu003Cdiv style="display:block; position: absolute; top:4px; width:100%; text-align:center;;"u003Eu003Cdiv style="font-weight:bold; color:#000085; font-size:14px; line-height:25px"u003Eu003Cdiv style="padding-left:50px;"u003Eu003C/divu003Eu003C/divu003Eu003Cdiv style="margin-top: 2px; font-weight:normal; color:#555; font-size:15px; line-height:15px;"u003Eu003Cdiv style="padding-left:50px;"u003EУ току је расправа о u003Cbu003Eu003Ca href="/wiki/%D0%92%D0%B8%D0%BA%D0%B8%D0%BF%D0%B5%D0%B4%D0%B8%D1%98%D0%B0:%D0%93%D0%BB%D0%B0%D1%81%D0%B0%D1%9A%D0%B5/%D0%9F%D1%80%D0%B5%D0%B4%D0%BB%D0%BE%D0%B3/%D0%9F%D1%80%D0%B0%D0%B2%D0%BE_%D0%B0%D0%B4%D0%BC%D0%B8%D0%BD%D0%B8%D1%81%D1%82%D1%80%D0%B0%D1%82%D0%BE%D1%80_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D1%84%D0%B5%D1%98%D1%81%D0%B0" title="Википедија:Гласање/Предлог/Право администратор интерфејса"u003Eадминистраторима интерфејсаu003C/au003Eu003C/bu003E.u003C/divu003Eu003C/divu003Eu003C/divu003Eu003C/divu003Eu003C/divu003Enu003Cdiv class="noticebanner"u003Eu003Cdiv class="plainlinks" style="background-image: -moz-linear-gradient(top, #fefefe, #fefefe, #f0f0f0); background-image: -o-linear-gradient(top, #fefefe, #fefefe, #f0f0f0); background-image: -webkit-linear-gradient(top, #fefefe, #fefefe, #f0f0f0); background-image: linear-gradient(to bottom, #fefefe, #fefefe, #f0f0f0);; -moz-border-radius: 10px; -webkit-border-radius: 10px; border-radius:10px; margin-top:10px; position:relative; height:25px; border-style:solid; border-width:1px; color:#aaa; border-color:u0026#32;; border:; font-family: u0026#39;Helveticau0026#39;, u0026#39;Arialu0026#39;, sans-serif; line-height: 18px; background-color:; overflow:hidden;"u003Eu003Cdiv style="display:block; position: absolute; top:4px; width:100%; text-align:center;;"u003Eu003Cdiv style="font-weight:bold; color:#000085; font-size:14px; line-height:25px"u003Eu003Cdiv style="padding-left:50px;"u003Eu003C/divu003Eu003C/divu003Eu003Cdiv style="margin-top: 2px; font-weight:normal; color:#555; font-size:15px; line-height:15px;"u003Eu003Cdiv style="padding-left:50px;"u003EУ току су гласања о u003Cbu003Eu003Ca href="/wiki/%D0%92%D0%B8%D0%BA%D0%B8%D0%BF%D0%B5%D0%B4%D0%B8%D1%98%D0%B0:%D0%93%D0%BB%D0%B0%D1%81%D0%B0%D1%9A%D0%B5/%D0%9F%D0%BE%D0%B2%D0%B5%D1%9B%D0%B0%D1%9A%D0%B5_%D0%BF%D1%80%D0%BE%D1%81%D1%82%D0%BE%D1%80%D0%B0_%D0%B7%D0%B0_%D1%81%D0%BB%D0%B8%D0%BA%D0%B5_%D0%BD%D0%B0_%D0%B3%D0%BB%D0%B0%D0%B2%D0%BD%D0%BE%D1%98_%D1%81%D1%82%D1%80%D0%B0%D0%BD%D0%B8" title="Википедија:Гласање/Повећање простора за слике на главној страни"u003Eповећању простора за слике на Главној страниu003C/au003Eu003C/bu003E и u003Cbu003Eu003Ca href="/wiki/%D0%92%D0%B8%D0%BA%D0%B8%D0%BF%D0%B5%D0%B4%D0%B8%D1%98%D0%B0:%D0%93%D0%BB%D0%B0%D1%81%D0%B0%D1%9A%D0%B5/%D0%9F%D1%80%D0%B0%D0%B2%D0%B8%D0%BB%D0%B0_%D0%B7%D0%B0_%D0%BA%D0%BE%D1%80%D0%B8%D1%88%D1%9B%D0%B5%D1%9A%D0%B5_%D0%B8%D0%BC%D0%B5%D0%BD%D1%81%D0%BA%D0%BE%D0%B3_%D0%BF%D1%80%D0%BE%D1%81%D1%82%D0%BE%D1%80%D0%B0_%D0%9D%D0%B0%D1%86%D1%80%D1%82" title="Википедија:Гласање/Правила за коришћење именског простора Нацрт"u003Eкоришћењу именског простора Нацртu003C/au003Eu003C/bu003E.u003C/divu003Eu003C/divu003Eu003C/divu003Eu003C/divu003Eu003C/divu003Eu003C/divu003Eu003C/divu003Eu003C/divu003E";());




Polarna površina molekula




Из Википедије, слободне енциклопедије






Иди на навигацију
Иди на претрагу




Polarna površina paracetamola (crveno)


Polarna površina molekula (engl. Polar Surface Area - PSA) definiše se kao suma površina svih polarnih atoma, prvenstveno kiseonika i azota, uključujući atome vodonika koji su vezani za njih.[1][2]


PSA nalazi široku primenu u medicinskoj hemiji, kao parametar za optimizaciju sposobnosti leka da prodre u ćelije. Molekuli sa polarnom površinom većom od 140 angstroma kvadratnih ulavnom ispoljavaju slabu permeabilnost ćelijskih membrana. Da bi molekuli prošli kroz krvno-moždanu barijeru (i delovali na receptorima centralnog nervnog sistema), obično je neophodno da imaju PSA manju od 60 angstroma kvadratnih.



Vidi još


  • Lipinskijevo pravilo petice

  • Biofarmaceutski klasifikacioni sistem


  • Heminformatika
    • Chemistry Development Kit

    • JOELib



Reference




  1. ^ Ertl, P., Rohde, B., Selzer, P. Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties. J. Med. Chem. 2000, 43, 3714–3717. (doi:10.1021/jm000942e)


  2. ^ Ertl, P. Polar Surface Area, in Molecular Drug Properties, R. Mannhold (ed), Wiley-VCH, pp. 111–126, 2007




Spoljašnje veze



  • Interactive Polar Surface Area calculator

  • Free, Programmable TPSA Calculator




Преузето из „https://sr.wikipedia.org/w/index.php?title=Polarna_površina_molekula&oldid=9437677”










Мени за навигацију


























(window.RLQ=window.RLQ||[]).push(function()mw.config.set("wgPageParseReport":"limitreport":"cputime":"0.104","walltime":"0.137","ppvisitednodes":"value":167,"limit":1000000,"ppgeneratednodes":"value":0,"limit":1500000,"postexpandincludesize":"value":2516,"limit":2097152,"templateargumentsize":"value":389,"limit":2097152,"expansiondepth":"value":9,"limit":40,"expensivefunctioncount":"value":0,"limit":500,"unstrip-depth":"value":0,"limit":20,"unstrip-size":"value":1188,"limit":5000000,"entityaccesscount":"value":0,"limit":400,"timingprofile":["100.00% 108.561 1 -total"," 41.46% 45.008 1 Шаблон:Jez-eng-lat"," 24.53% 26.630 1 Шаблон:Reflist"," 12.95% 14.059 1 Шаблон:DOI"," 8.15% 8.847 1 Шаблон:Portal-lat"," 5.80% 6.302 2 Шаблон:Hide_in_print"," 2.32% 2.514 1 Шаблон:Str_left"," 2.02% 2.197 1 Шаблон:Only_in_print"," 1.89% 2.051 1 Шаблон:Main_other"],"scribunto":"limitreport-timeusage":"value":"0.015","limit":"10.000","limitreport-memusage":"value":1023161,"limit":52428800,"cachereport":"origin":"mw1299","timestamp":"20190316164037","ttl":2592000,"transientcontent":false););"@context":"https://schema.org","@type":"Article","name":"Polarna povru0161ina molekula","url":"https://sr.wikipedia.org/wiki/Polarna_povr%C5%A1ina_molekula","sameAs":"http://www.wikidata.org/entity/Q7209103","mainEntity":"http://www.wikidata.org/entity/Q7209103","author":"@type":"Organization","name":"u0421u0430u0440u0430u0434u043du0438u0446u0438 u043fu0440u043eu0458u0435u043au0430u0442u0430 u0412u0438u043au0438u043cu0435u0434u0438u0458u0435","publisher":"@type":"Organization","name":"Wikimedia Foundation, Inc.","logo":"@type":"ImageObject","url":"https://www.wikimedia.org/static/images/wmf-hor-googpub.png","datePublished":"2014-01-29T18:55:13Z","dateModified":"2014-01-29T19:02:18Z","image":"https://upload.wikimedia.org/wikipedia/commons/7/7e/Polar-surface-area.png"(window.RLQ=window.RLQ||[]).push(function()mw.config.set("wgBackendResponseTime":156,"wgHostname":"mw1320"););
-

Popular posts from this blog

How to make RAID controller rescan devices The 2019 Stack Overflow Developer Survey Results Are InLSI MegaRAID SAS 9261-8i: Disk isn't recognized after replacementHow to monitor the hard disk status behind Dell PERC H710 Raid Controller with CentOS 6?LSI MegaRAID - Recreate missing RAID 1 arrayext. 2-bay USB-Drive with RAID: btrfs RAID vs built-in RAIDInvalid SAS topologyDoes enabling JBOD mode on LSI based controllers affect existing logical disks/arrays?Why is there a shift between the WWN reported from the controller and the Linux system?Optimal RAID 6+0 Setup for 40+ 4TB DisksAccidental SAS cable removal

Image
Is "plugging out" electronic devices an American expression? Does a dangling wire really electrocute me if I'm standing in water? Adding labels to a table: columns and rows Spanish for "widget" Landlord wants to switch my lease to a "Land contract" to "get back at the city" Lethal sonic weapons On the insanity of kings as an argument against monarchy Is there a general name for the setup in which payoffs are not known exactly but players try to influence each other's perception of the payoffs? How long do I have to send my income tax payment to the IRS? Geography at the pixel level Can a zener diode with a higher power dissipation be used in place of the original one in an audio amplifier? How can I make payments on the Internet without leaving a money trail? What can other administrators access on my machine? Understanding the implication of what "well-defined" means for the operation in quotient group...
Read more

How can I have a shield and a way of attacking at distance at the same time? The 2019 Stack Overflow Developer Survey Results Are InDoes the Thrown property mean I can attack with my DEX?Is it possible to build a custom weapon, and if so, how will my character be able to use it?Can the Ghost Touch weapon property allow an attacker to perform incorporeal touch attacks?The DM allowed me to wield two shields, how can I get the most AC and HP, as a Bear Barbarian?Are there ways other than Kensei Weapons or Hex Warrior to use an ability other than STR for non-finesse melee weapons?Cheapest way to cast spells with sword and (heavy) shield?Is this homebrew “Throwing Weapons Master” feat balanced?Can Hexblade warlocks use a staff and shield?Are there any balance issues with allowing thrown Javelins to be drawn for free like ammunition weapons?Does an unattuned Frost Brand weapon still glow in freezing temperatures?Does a druid starting with a bow start with no arrows?Is it possible to build a custom weapon, and if so, how will my character be able to use it?

Image
Did the UK government pay "millions and millions of dollars" to try to snag Julian Assange? If I score a critical hit on an 18 or higher, what are my chances of getting a critical hit if I roll 3d20? Why can't devices on different VLANs, but on the same subnet, communicate? Are Newtonian Mechanics considered to be 'falsified'? The phrase "to the numbers born"? How can I add encounters in the Lost Mine of Phandelver campaign without giving PCs too much XP? Does adding complexity mean a more secure cipher? How to read αἱμύλιος or when to aspirate Using `min_active_rowversion` for global temporary tables Does Parliament need to approve the new Brexit delay to 31 October 2019? Did researcher Katie Bouman only contributed 0.26% of code that created Black Hole image? Is it ethical to upload a automatically generated paper to a non peer-reviewed site as part of a larger research? Taking the derivative of a differential equation ...
Read more

How many cones with angle theta can I pack into the unit sphere? The 2019 Stack Overflow Developer Survey Results Are InPacking space by cones: Translates best?Covering a unit ball with balls half the radiusOptimal pebble-packing shapeHow many unit balls can be put into a unit cube?Computing the Volume of Closed 3-Manifolds and the Geometrization ConjectureIs it true that a solid, minihedral cone in infinite dimensions cannot be regular?Is there an “accepted” jamming limit for hard spheres placed in the unit cube by random sequential adsorption?Sphere packings with antipodal (unequal) spheresThe Disco Ball ProblemDo kissing numbers with distance $d$ always grow polynomially or exponentially in dimension?

Image
How many cones with angle theta can I pack into the unit sphere? The 2019 Stack Overflow Developer Survey Results Are InPacking space by cones: Translates best?Covering a unit ball with balls half the radiusOptimal pebble-packing shapeHow many unit balls can be put into a unit cube?Computing the Volume of Closed 3-Manifolds and the Geometrization ConjectureIs it true that a solid, minihedral cone in infinite dimensions cannot be regular?Is there an “accepted” jamming limit for hard spheres placed in the unit cube by random sequential adsorption?Sphere packings with antipodal (unequal) spheresThe Disco Ball ProblemDo kissing numbers with distance $d$ always grow polynomially or exponentially in dimension? 3 1 $begingroup$ Given a unit sphere (radius 1), I would like to know how many cones I can pack into this unit sphere. Restrictions: The top of the cone needs to be in the center of origin. The bottom of the cone needs to form a circle on the unit sphere. I ...
Read more