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Particioni koeficijent Садржај Vidi još Reference Literatura Spoljašnje veze Мени за навигацију10.1021/cr60274a001„Partition Coefficient”10.1351/goldbook„Partition Coefficient”10.1351/goldbookBioByte ClogP/Bio-LoomACD/LogP DB

Хемија равнотежеМедицинска хемијаОрганска хемија


hemijifarmaceutskim naukamakoncentracijajedinjenjarastvaračaekvilibrijumuHenrijevog zakonarastvorljivostivodahidrofobanoktanolahidrofilnostihidrofobnostilipidnih dvoslojevakrvni serum










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Particioni koeficijent




Из Википедије, слободне енциклопедије






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U hemiji i farmaceutskim naukama, particioni- (P) ili distribucioni koeficijent (D) je odnos koncentracija jedinjenja u dve faze mešavine dva nemešiva rastvarača u ekvilibrijumu.[1] Termini "gas/tečnost particioni koeficijent" i "vazduh/voda particioni koeficijent" se ponekad koriste za bezdimenzione forme konstante Henrijevog zakona. Stoga su ti koeficijenti mera diferencijalne rastvorljivosti jedinjenja između ta dva rastvarača. Fraza „particioni koeficijent“ se u današnje vreme smatra zastarelom po IUPAC-u, i „particiona konstanta“, „particioni odnos“, ili „distribucioni odnos“, su prikladniji termini.[2]


Normalno se kao jedan od rastvarača koristi voda dok je drugi hidrofoban poput oktanola.[3] Stoga je logP mera hidrofilnosti ili hidrofobnosti hemijske supstance. Particioni koeficijent se isto tako može koristiti kad je jedan ili oba rastvarača čvrst. U medicinskoj praksi, particioni koeficijenti su korisni na primer za procenu distribucije leka u telu. Hidrofobni lekovi sa visokim particionim koeficijentima su preferentno distribuirani u hidrofobnim kompartmanima poput lipidnih dvoslojeva ćelija dok su hidrofilni lekovi (niski particioni koeficijenti) preferentno nalaze u hidrofilnim kompartmanima kao što je krvni serum.




Садржај





  • 1 Vidi još


  • 2 Reference


  • 3 Literatura


  • 4 Spoljašnje veze




Vidi još



  • Hemoinformatika
    • ADME

    • Lipinskijevo pravilo petice

    • QSAR


  • JOELib


Reference




  1. ^ Leo A, Hansch C, Elkins D (1971). „Partition coefficients and their uses”. Chem Rev. 71 (6): 525—616. doi:10.1021/cr60274a001. 


  2. ^ Wilkinson, Andrew M.; McNaught, Alan D. (1997). „Partition Coefficient”. Compendium of Chemical Terminology: IUPAC Recommendations. Oxford: Blackwell Science. doi:10.1351/goldbook. ISBN 0-86542-684-8. 


  3. ^ Sangster, James (1997). Octanol-Water Partition Coefficients: Fundamentals and Physical Chemistry, Vol. 2 of Wiley Series in Solution Chemistry. Chichester: John Wiley & Sons Ltd. стр. 178 pages. ISBN 978-0471973973. 



Literatura



  • Sangster, James (1997). Octanol-Water Partition Coefficients: Fundamentals and Physical Chemistry, Vol. 2 of Wiley Series in Solution Chemistry. Chichester: John Wiley & Sons Ltd. стр. 178 pages. ISBN 978-0471973973. 


  • Wilkinson, Andrew M.; McNaught, Alan D. (1997). „Partition Coefficient”. Compendium of Chemical Terminology: IUPAC Recommendations. Oxford: Blackwell Science. doi:10.1351/goldbook. ISBN 0-86542-684-8. 


Spoljašnje veze


  • BioByte ClogP/Bio-Loom

  • ACD/LogP DB




Преузето из „https://sr.wikipedia.org/w/index.php?title=Particioni_koeficijent&oldid=12151153”










Мени за навигацију


























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